1-(4-(Trifluoromethyl)phenyl)piperazine → (5-Bromo-2-morpholin-4-yl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

HRID 736232Notes

Reaction equation

HRID 736232 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[C:6]([CH:10]=1)[C:7](Cl)=[O:8].[F:17][C:18]([F:32])([F:31])[C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:21][CH:20]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[C:6]([C:7]([N:28]2[CH2:27][CH2:26][N:25]([C:22]3[CH:21]=[CH:20][C:19]([C:18]([F:31])([F:32])[F:17])=[CH:24][CH:23]=3)[CH2:30][CH2:29]2)=[O:8])[CH:10]=1

Participants

3

Reactant 2

HCID 1217181-(4-(Trifluoromethyl)phenyl)piperazineHCID 597935145-Bromo-2-morpholin-4-yl-benzoyl chloride

Product 1

HCID 59793730(5-Bromo-2-morpholin-4-yl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

Procedure

Example CR was prepared in analogy to Example 46 from 5-Bromo-2-morpholin-4-yl-benzoyl chloride (example BI) and 1-(4-Trifluoromethyl-phenyl)-piperazine (commercial). MS (m/e): 500.1 (M+H+, 100%).

Sources & evidence

ORD record
ord-a0ecc6b60a6947b3911ec7ebbeec6c8b
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

Loading…