HRID736235

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID17942383

2-Cyclopropyl-1H-imidazole

C6H8N2

结构：O=C(c1cc(Br)ccc1N1CCOCC1)N1CCN(c2ccc(C(F)(F)F)cc2)CC1

HCID59793730

未命名化合物

PRODUCTS

生成物

结构：O=C(c1cc(-n2ccnc2C2CC2)ccc1N1CCOCC1)N1CCN(c2ccc(C(F)(F)F)cc2)CC1

HCID68841917

未命名化合物

收率 16%

PROCEDURE

实验过程

The title compound was prepared according to the procedure described for example 199 from (5-Bromo-2-morpholin-4-yl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone (compound CR) and 2-Cyclopropyl-1H-imidazole (CAS: 89532-38-7) (16% yield, white solid, MS (m/e): 526.3 (M+H, 100%)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-079f3da0462b4aa58a68ba1f2444ec9f
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07595314B2
来源说明: uspto-grants-2009_09

反应 SMILES

Br[C:2]1[CH:3]=[CH:4][C:5]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)=[C:6]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)=[O:9])[CH:7]=1.[CH:32]1([C:35]2[NH:36][CH:37]=[CH:38][N:39]=2)[CH2:34][CH2:33]1>>[CH:32]1([C:35]2[N:36]([C:2]3[CH:3]=[CH:4][C:5]([N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)=[C:6]([C:8]([N:10]4[CH2:15][CH2:14][N:13]([C:16]5[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=5)[CH2:12][CH2:11]4)=[O:9])[CH:7]=3)[CH:37]=[CH:38][N:39]=2)[CH2:34][CH2:33]1