4-Methylpyrazole → [5-Methanesulfonyl-2-(4-methyl-pyrazol-1-yl)-phenyl]-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

Participants

Role	Name	HCID	Charge
Reactant	4-Methylpyrazole	HCID 3406	—
Reactant	(2-Iodo-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone	HCID 59793691	—
Product	[5-Methanesulfonyl-2-(4-methyl-pyrazol-1-yl)-phenyl]-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone	HCID 68841019	43%

Reaction Steps

The title compound was prepared according to the procedure described for example 294 from (2-Iodo-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone (compound CK) and 4-Methyl-1H-pyrazole (43% yield, white solid, MS (m/e): 493.1 (M+H, 100%)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07595314B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-5322f61c1efb4aa190956b2606c4eb1c
Source note	uspto-grants-2009_09