Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | HCID 178478418 | HCID 178478418 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | 845617-09-6 | HCID 86600711 | — |
Reaction Steps
A solution of 11 mmol of 2,4-dichlorotriazine (WO 02/083654) in 20 ml of acetonitrile was chilled and treated with 11 mmol of triethylamine and 11 mmol of N-BOC-piperazine. The reaction mixture was stirred for 2 hours at 0° C. then for 2 hours at room temperature. Addition of 100 ml brine and extraction with ethyl acetate yielded the crude product which was purified through trituration in ethyl acetate. MS (m/e): 300.3 (MH+, 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07595314B2 |
|---|
| Source dataset | uspto-grants-2009_09 |
|---|
| ORD ID | ord-4609ba04ec46453fa146ffc37f1d7ecc |
|---|
| Source note | uspto-grants-2009_09 |
|---|
