HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 736251Generated: October 29, 2026
Trifluoroacetic acid → HCID 59793503, compound
https://huagongshe.com/reaction/736251
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(4-Dimethylamino-[1,3,5]triazin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 68903194 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59793503 | HCID 59793503 | — |
Reaction Steps
A solution of 1 mmol of 4-(4-Dimethylamino-[1,3,5]triazin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester in 10 ml dichloromethane was chilled and treated with 14 mmol of trifluoroacetic acid. The reaction mixture was heated to 40° C. for 30 min. After cooling, 50 ml of 2M aqueous sodium hydroxide is added. The organic layer was separated, dried and concentrated to yield the title compound as a yellowish oil. MS (m/e): 267.0 (M+CH3COO+, 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07595314B2 |
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| Source dataset | uspto-grants-2009_09 |
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| ORD ID | ord-0ec980e3017748a8a3de6370fbf97e95 |
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| Source note | uspto-grants-2009_09 |
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