HCID 57848858, compound → HCID 178480826, compound

Participants

Reaction Steps

A solution of 0.14 g (232 μmol) of tert-butyl 5-(N′-methyl-N′-phenylhydrazinocarbonyl)-3-[4-(4-methylpiperazin-1-ylmethyl)benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylate in 8 mL of methanol is introduced into a microwave oven tube. The tube is stoppered and the reaction mixture is irradiated at a temperature in the region of 100° C. for 20 minutes, and then for two further periods of 15 minutes. The reaction mixture is then concentrated to dryness under vacuum (2 kPa) at a temperature in the region of 35° C. The residue is taken up in 15 mL of diisopropyl ether, triturated, filtered on a sinter funnel, washed twice with 5 mL of diisopropyl ether, suction-filtered and then dried in an oven under vacuum (0.01 kPa) at a temperature in the region of 60° C. 78 mg of N-[5-(N′-methyl-N′-phenylhydrazinocarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-ylmethyl)benzamide are thus obtained in the form of an off-white solid melting at 246° C. LC-MS-DAD-ELSD: 504(+)=(M+H)(+); 502(−)=(M−H)(−).

Provenance & Evidence