HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Amino-4-methylpiperazine → 4-(4-methylpiperazin-1-ylaminomethyl)-N-[2-fluoro-5-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Amino-4-methylpiperazine | HCID 81349 | — |
| Reactant | HCID 68816925 | HCID 68816925 | — |
| Product | 4-(4-methylpiperazin-1-ylaminomethyl)-N-[2-fluoro-5-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide | HCID 68820158 | 53.2% |
Reaction Steps
1-Amino-4-methylpiperazine (0.66 g, 5.77 mol) and N-[4-fluoro-3-(4-chloromethyl benzoylamino)-phenyl]-4-(3-pyridyl)-2-pyrimidine-amine (1 g, 2.31 mmol) were reacted according to the same procedure as Example 3 to give 4-(4-methylpiperazin-1-ylaminomethyl)-N-[2-fluoro-5-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide (0.63 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595323B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-895e70c42cc64266be457af3c34736f0 |
| Source note | uspto-grants-2009_09 |