2-Fluorophenyl isocyanate → 1-[2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-4-yl]-3-(2-fluoro-phenyl)-urea

Participants

Reaction Steps

The title compound was prepared from 1-fluoro-2-isocyanato-benzene (0.05 mL, 0.41 mmol) and (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(4-amino-pyridin-2-yl)-methanone (0.10 g, 0.34 mmol) by procedures analogous to those described for the preparation of 1-[4-(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-2-yl]-3-(2-fluoro-phenyl)-urea. MS: 434.1 (MH+); HPLC Rf: 2.6 min. (HPLC method 2).

Provenance & Evidence