2-Fluorobenzenesulphonyl chloride → N-[2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-4-yl]-2-fluoro-benzenesulfonamide

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Reaction Steps

The title compound was prepared from 2-fluoro-benzenesulfonyl chloride (0.53 mL, 0.41 mmol) and (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(4-amino-pyridin-2-yl)-methanone (0.10 g, 0.34 mmol) by procedures analogous to those described for the preparation of N-[4-(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-2-yl]-2-fluoro-benzenesulfonamide. MS: 455.3 (MH+); HPLC Rf: 2.4 min. (HPLC method 2).

Provenance & Evidence