Ammonium Hydroxide → HCID 68904398, compound

Participants

Reaction Conditions

Reaction Steps

[2-(Benzhydrylidene-amino)-6-methoxy-pyridin-4-yl]-(4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone (7.31 g, 14.3 mmol) was added to a solution of ammonium hydroxide (150 mL) in dioxane (150 mL) and stirred at 45° C. in a sealed tube for 12 h. The reaction mixture was concentrated in vacuo, dissolved in hot CH2Cl2 (150 mL), and washed with water (3×100 mL). The aqueous layer was extracted with CH2Cl2 (3×100 mL) and the combined organic extracts were dried (Na2SO4), filtered, and concentrated in vacuo to provide the title compound as a yellow solid (3.43 g, 73%). MS: 327.2 (MH−); HPLC Rf: 2.1 min. (HPLC method 2).

Provenance & Evidence