2-Fluorobenzenesulphonyl chloride → HCID 68906522, compound

Participants

Reaction Steps

2-Fluoro-benzenesulfonyl chloride (0.05 mL, 0.37 mmol) was added to a solution of (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(2-amino-6-methoxy-pyridin-4-yl)-methanone (100 mg, 0.31 mmol) in pyridine (2 mL) and stirred for 2 h at room temperature. The reaction mixture was quenched with H2O (100 mL) and extracted with hot EtOAC/MeOH (95:5 3×100 mL). The combined organic extracts were cooled to room temperature and the solid was filtered and dried to provide the title compound as a white solid (69 mg, 47%). MS: 485.3 (MH+); HPLC Rf: 2.7 min. (HPLC method 2); HPLC purity: 100%.

Provenance & Evidence