1-(Propan-2-yl)-1,3-dihydro-2H-benzimidazol-2-one → Methyl 2-ethyl-2-{[4-({[(3-isopropyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)carbonyl]amino}methyl)piperidin-1-yl]methyl}butanoate

HRID 736427Notes

Reaction equation

HRID 736427 reaction equation
[CH:1](N1C2C=CC=CC=2NC1=O)(C)C.[CH2:14]([C:16]([CH2:22][N:23]1[CH2:28][CH2:27][CH:26]([CH2:29][NH:30][C:31]([N:33]2[C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=3[N:35]([CH:42]([CH3:44])[CH3:43])[C:34]2=[O:45])=[O:32])[CH2:25][CH2:24]1)([CH2:20][CH3:21])[C:17]([OH:19])=[O:18])[CH3:15]>>[CH2:14]([C:16]([CH2:22][N:23]1[CH2:24][CH2:25][CH:26]([CH2:29][NH:30][C:31]([N:33]2[C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=3[N:35]([CH:42]([CH3:43])[CH3:44])[C:34]2=[O:45])=[O:32])[CH2:27][CH2:28]1)([CH2:20][CH3:21])[C:17]([O:19][CH3:1])=[O:18])[CH3:15]

Participants

3

Reactant 2

HCID 16535801-(Propan-2-yl)-1,3-dihydro-2H-benzimidazol-2-oneHCID 578489352-ethyl-2-{[4-({[(3-isopropyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)carbonyl]amino}methyl)piperidin-1-yl]methyl}butanoic acid

Product 1

HCID 68585368Methyl 2-ethyl-2-{[4-({[(3-isopropyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)carbonyl]amino}methyl)piperidin-1-yl]methyl}butanoate

Procedure

The title compound was prepared according to the procedure described in Step 2 of Example 8 from 1-isopropyl-1,3-dihydro-2H-benzimidazol-2-one and Methyl 2-[(4-{[(tert-butoxycarbonyl)amino]methyl}piperidin-1-yl)methyl]-2-ethylbutanoate (step 1 of Example 13).

Sources & evidence

ORD record
ord-cf380ebb05e8487fb19a1ec382ce46d6
Source dataset
uspto-grants-2009_09
Patent number
US07595329B2

Reaction notes

Loading…