tert-Butyl [(4-fluoropiperidin-4-yl)methyl]carbamate → HCID 86602124, compound

HRID 736429Notes

Reaction equation

HRID 736429 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1([F:16])[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].I[CH2:18][C:19]1([C:25]([O:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[O:26])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[CH2:28]([O:27][C:25]([C:19]1([CH2:18][N:13]2[CH2:12][CH2:11][C:10]([CH2:9][NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:2])[CH3:3])([F:16])[CH2:15][CH2:14]2)[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1)=[O:26])[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 53415226tert-Butyl [(4-fluoropiperidin-4-yl)methyl]carbamateHCID 68584738HCID 68584738, compound

Product 1

HCID 86602124HCID 86602124, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 3 from 4-tert-butoxycarbonylaminomethyl-4-fluoropiperidine (step 4 of Example 15) and benzyl 4-iodomethyltetrahydropyran-4-yl-carboxylate (step 2 of Example 15).

Sources & evidence

ORD record
ord-583c82f796d74a748a2fc3e959e830ab
Source dataset
uspto-grants-2009_09
Patent number
US07595329B2

Reaction notes

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