Hydroxyamine hydrochloride → 5-(4-chlorophenyl)-3-(hydroxyamino)-8-methyl-7,9-dihydro-6H-pyrrolo[3,2-h]isoquinolin-2-one;hydrochloride

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Reaction Steps

A mixture of 5-(4-chlorophenyl)-8-methyl-6,7,8,9-tetrahydro-1-H-pyrrolo[3.2-h]isoquinoline-2,3-dione (0.50 g, 1.53 mmol), hydroxylamine hydrochloride (0.5 g, 7.2 mmol) and ethanol (5 ml, 96%) was stirred at room-temperature for 15 minutes. The colour shifted from yellow to red and the product precipitated. The product was filtered and 0.44 g (76%) was isolated. Mp decomp. 300-305° C.

Provenance & Evidence