HCID 57849005, compound → HCID 57849018, compound

Participants

Reaction Steps

To a solution of 650 mg (1.92 mmol) 5-2 in 50 mL of Et2O cooled to 0° C. was added dropwise 670 μL (2.02 mmol) 3M PhMgBr in Et2O. This mixture was stirred for 30 min, quenched with a solution of saturated NH4Cl, dumped into a separatory funnel containing EtOAc, the layers were separated, and the organic phase was washed with brine, dried over Na2SO4, and concentrated. The residue was purified by silica gel chromatography with EtOAc/hexanes to provide 5-3 as a yellow oil. Data for 5-3: 1HNMR (500 MHz, CDCl3) δ 7.65 (m, 1H), 7.5-7.3 (m, 4H), 7.15 (m, 2H), 6.85 (m, 1H), 4.8 (s, 2H), 4.55 (m, 1H), 4.05 (m, 2H), 3.7 (m, 2H), 3.0 (m, 2H), 2.0 (m, 1H), 1.7 (m, 2H), 1.3 (m, 1H) ppm, LC-MS: rt=2.9 min, m/z=369 (M+1).

Provenance & Evidence