HCID 57849340, compound → HCID 57849324, compound

HRID 736526Notes

Reaction equation

HRID 736526 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([C:20]2[CH:30]=[CH:29][C:23]([O:24][CH2:25][C:26]([OH:28])=O)=[C:22]([CH3:31])[CH:21]=2)([CH2:18][CH3:19])[CH2:16][CH3:17])=[CH:11][C:10]=1[CH3:32])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH3:34][N:35](C)[O:36][CH3:37]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([C:20]2[CH:30]=[CH:29][C:23]([O:24][CH2:25][C:26]([N:35]([O:36][CH3:37])[CH3:34])=[O:28])=[C:22]([CH3:31])[CH:21]=2)([CH2:16][CH3:17])[CH2:18][CH3:19])=[CH:11][C:10]=1[CH3:32])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 57849340HCID 57849340, compoundHCID 86622592120716-83-8

Product 1

HCID 57849324HCID 57849324, compoundYield 77.2%

Procedure

Using an analogous procedure to Example 1J, {4-[1-(4-benzyloxy-3-methyl-phenyl)-1-ethyl-propyl]-2-methyl-phenoxy}-acetic acid (1.46 g, 3.38 mmol) and N,O-dimethylmethylhydroxyamine hydrochloride (363 mg, 3.72 mmol) give the title compound (1.24 g, 2.61 mmol, 77%).

Sources & evidence

ORD record
ord-9d228fd0e79145a5b5eeab617c636cbf
Source dataset
uspto-grants-2009_09
Patent number
US07595345B2

Reaction notes

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