HCID 57849324, compound → HCID 57849366, compound

Participants

Reaction Conditions

Reaction Steps

To a 0° C. solution of 2-{4-[1-(4-benzyloxy-3-methyl-phenyl)-1-ethyl-propyl]-2-methyl-phenoxy}-N-methoxy-N-methyl-acetamide (2.36 g, 4.98 mmol) in THF (50 mL) is added 2.0 M iPrMgCl (3.0 mL, 5.98 mmol). The reaction is stirred at 0° C. for 30 m, then at RT for 1 h. It is quenched with satd NH4Cl (20 mL), diluted with H2O (50 mL), extracted with EtOAc (2×100 mL), washed with 0.1 M HCl (50 mL), H2O (50 mL); MgSO4 dried, concentrated and purified to give the title compound (1.01 g, 2.21 mmol, 44%).

Provenance & Evidence