Glycine methyl ester hydrochloride → HCID 57849332, compound

HRID 736529Notes

Reaction equation

HRID 736529 reaction equation
[CH2:1]([C:3]([C:23]1[CH:31]=[CH:30][C:26]([C:27](O)=[O:28])=[C:25]([CH3:32])[CH:24]=1)([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]([OH:21])([CH:18]([CH3:20])[CH3:19])[CH:15]([CH3:17])[CH3:16])=[C:8]([CH3:22])[CH:7]=1)[CH2:4][CH3:5])[CH3:2].Cl.[CH3:34][O:35][C:36](=[O:39])[CH2:37][NH2:38]>>[CH3:34][O:35][C:36](=[O:39])[CH2:37][NH:38][C:27](=[O:28])[C:26]1[CH:30]=[CH:31][C:23]([C:3]([CH2:4][CH3:5])([C:6]2[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]([OH:21])([CH:18]([CH3:19])[CH3:20])[CH:15]([CH3:16])[CH3:17])=[C:8]([CH3:22])[CH:7]=2)[CH2:1][CH3:2])=[CH:24][C:25]=1[CH3:32]

Participants

3

Reactant 2

HCID 122755Glycine methyl ester hydrochlorideHCID 57849338HCID 57849338, compound

Product 1

HCID 57849332HCID 57849332, compoundYield 86.8%

Procedure

Using a procedure analogous to Example 1J, 4-{1-ethyl-1-[4-(2-hydroxy-2-isopropyl-3-methyl-butoxy)-3-methyl-phenyl]-propyl}-2-methyl-benzoic acid (0.30 g, 0.68 mmol) and glycine methyl ester hydrochloride (0.094 g, 0.75 mmol) gives the titled compound (0.30 g, 0.59 mmol, 86%).

Sources & evidence

ORD record
ord-7c864acbedf64ee5a8cef173af3dc6a0
Source dataset
uspto-grants-2009_09
Patent number
US07595345B2

Reaction notes

Loading…