1,2-Benzisothiazol-3(2H)-one → 3-Oxo-3H-benzo[d]isothiazole-2-carboxylic acid hexylamide

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Reaction Steps

Following the synthetic procedure of 6a as described in Example 1, compound 6e (82% yield) was synthesized from benzo[d]isothiazol-3-one and n-hexyl isocyanate as a white solid. mp 52-53° C.; IR(CHCl3) 3290, 1711, 1662, 1540 cm−1; 1H-NMR (CDCl3) δ0.80-0.87 (m, 3H), 1.21-1.35 (m, 6H), 1.53-1.61 (m, 2H), 3.34-3.40 (m, 2H), 7.36 (t, J=7.6 Hz, 1H), 7.51 (d, J=7.6 Hz, 1H), 7.63 (t, J=7.6 Hz, 1H), 7.95 (d, J=6.9 Hz, 1H), 8.81 (br s, 1H); ESIMS m/e 279 (M++1).

Provenance & Evidence