1,2-Benzisothiazol-3(2H)-one → 3-Oxo-3H-benzo[d]isothiazole-2-carboxylic acid 3-methyl-benzylamide

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Reaction Steps

Following the synthetic procedure of 6a as described in Example 1, compound 6k (37% yield) was synthesized from benzo[d]isothiazol-3-one and 3-methylbenzyl isocyanate as a white solid. mp 153-155° C.; IR(CHCl3) 3281, 1711, 1650,1534 cm−1; 1H-NMR (DMSO-d6) δ2.28 (s, 3H), 4.49 (d, J=5.9 Hz, 2H), 7.07 (d, J=7.5 Hz, 1H), 7.12-7.16 (m, 2H), 7.22 (t, J=7.5 Hz, 1H), 7.48 (t, J=7.8 Hz, 1H), 7.78 (t, J=8.2 Hz, 1H), 7.93 (d, J=7.8 Hz, 1H), 8.01 (d, J=8.2 Hz, 1H), 9.25 (br t, J=5.9 Hz, 1H); ESIMS m/e 299 (M++1).

Provenance & Evidence