HCID 57955164, compound → N-{4-[4-amino-7-formyl-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl}-N'-[2-fluoro-5-(trifluoro-methyl)phenyl]urea

HRID 73663Notes

Reaction equation

HRID 73663 reaction equation
[NH2:1][C:2]1[C:7]2=[C:8]([C:15]3[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:24][C:25]4[CH:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[CH:27][C:26]=4[F:35])=[O:23])=[CH:17][CH:16]=3)[C:9]([CH2:12][O:13][CH3:14])=[C:10](Br)[N:6]2[N:5]=[CH:4][N:3]=1.NC1C2=C(C3C=CC(NC(NC4C=C(C(F)(F)F)C=CC=4F)=O)=CC=3)C([C:47](NCC(F)(F)F)=[O:48])=C(Br)N2N=CN=1>>[NH2:1][C:2]1[C:7]2=[C:8]([C:15]3[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:24][C:25]4[CH:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[CH:27][C:26]=4[F:35])=[O:23])=[CH:17][CH:16]=3)[C:9]([CH2:12][O:13][CH3:14])=[C:10]([CH:47]=[O:48])[N:6]2[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 57955164HCID 57955164, compoundHCID 57955304HCID 57955304, compound

Product 1

HCID 57955296N-{4-[4-amino-7-formyl-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl}-N'-[2-fluoro-5-(trifluoro-methyl)phenyl]urea

Procedure

The procedure used for the preparation of Intermediate AU was used to prepare the title compound by substituting Intermediate AV (N-{4-[4-amino-7-bromo-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl}-N′-[2-fluoro-5-(trifluoro-methyl)phenyl]urea) for Intermediate AT (4-amino-7-bromo-5-{4-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenyl}-N-(2,2,2-trifluoroethyl)-pyrrolo-[2,1-f][1,2,4]triazine-6-carboxamide). The title compound was obtained as isolated and was used without further purification. MS [M+H]+=503; LCMS RT=3.21 min.

Sources & evidence

ORD record
ord-97a8062b973d43a4a4bfc7bc242eb5e2
Source dataset
uspto-grants-2014_09
Patent number
US08829185B2

Reaction notes

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