N-bromobutanimide → HCID 136047089, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of purinone from step 2 (0.29 g, 1.21 mmol) from above reaction in dioxane (0.1M) is added NBS (0.32 g, 1.81 mmol). The resulting reaction mixture was heated to 105° C. until HPLC shows consumption of starting material (ca. 2 h). The reaction was cooled to rt and purified by MPLC using a solvent gradient of 0-20% MeOH/CH2Cl2. The product containing fractions were collected and concentrated to provide the desired product (0.22 g, 57% yield). 1H NMR (DMSO-d6) δ 12.49 (s, 1H), 8.08 (s, 1H), 7.30-7.21 (m, 3H), 7.10-7.04 (m, 2H), 4.36 (t, J=7.0 Hz, 2H), 3.17 (t, J=7.3 Hz, 2H).

Provenance & Evidence