Thionyl Chloride → HCID 22568265, compound

HRID 736653Notes

Reaction equation

HRID 736653 reaction equation
[CH2:1]([N:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH:5]1[CH2:10][CH2:11]O)[CH2:2][CH3:3].S(Cl)([Cl:15])=O>ClCCl>[Cl:15][CH2:11][CH2:10][CH:5]1[CH2:6][CH2:7][CH2:8][CH2:9][N:4]1[CH2:1][CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 21153799HCID 21153799, compound

Product 1

HCID 22568265HCID 22568265, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-(1-propyl-piperidin-2-yl)-ethanol (0.150 g, 0.875 mmol) in dichloromethane (5 mL) was added thionyl chloride (1.0 mL, 13.70 mmol) at room temperature and the reaction mixture was refluxed for 3 h. The solvent and excess thionyl chloride was removed under reduced pressure. The product was dissolved in dichloromethane and evaporated to dryness. The product was used for the next step without further purifications. GC-MS m/z 189.00

Workup

  1. temperaturethe reaction mixture was refluxed for 3 h
  2. customThe solvent and excess thionyl chloride was removed under reduced pressure
  3. dissolutionThe product was dissolved in dichloromethane
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-940b55a4964d490bad2d3efd02d6f7aa
Source dataset
uspto-grants-2009_09
Patent number
US07595401B2

Reaction notes

Loading…