Carbon tetrabromide → HCID 57850288, compound

Participants

Reaction Conditions

Reaction Steps

The 1-(1-cyclopropyl-3-hydroxy-propyl)-3-isopropyl-urea (0.189 g, 0.950 mmol) was then dissolved in CH2Cl2 (10 mL) and CBr4 (0.477 g, 1.40 mmol) was added and the mixture was cooled to 0° C. To the mixture was added PPh3-polymer-bound resin (0.889 g, 1.40 mmol; 1.6 mmol/g) in portionwise. After stirring for at rt for 3 h, the mixture was diluted with CH2Cl2 (50 mL), filtered, and washed with CH2Cl2/MeOH/Acetone. The combined filtrates were concentrated in vacuo to give 1-(3-Bromo-1-cyclopropyl-propyl)-3-isopropyl-urea (0.212 g). GC-MS m/z 262.

Provenance & Evidence