HCID 59154175, compound → HCID 57850422, compound

Participants

Reaction Steps

The alkylation reaction was carried out according to the procedure described for example 1 and 2 using 8-(6-Bromo-benzo[1,3]dioxol-5-ylsulfanyl)-9H-purin-6-ylamine (0.172 g, 0.47 mmol) and 2-[1-((2R)-2-{[tert-butyl-(diphenyl)-silyl]-oxy}-propanoyl)-piperidin-4-yl]-ethyl 4-methylbenzenesulfonate (0.280 g, 0.47 mmol) obtained from step 3 to afford 8-[(6-bromo-1,3-benzodioxol-5-yl)thio]-9-{2-[1-((2R)-2-{[tert butyl(diphenyl)silyl]oxy}propanoyl)piperidin-4-yl]ethyl}-9H-purin-6-amine; LC-MS [M+1]+ 787.1 and 8-[(6-bromo-1,3-benzodioxol-5-yl)thio]-3-{2-[1-((2R)-2-{[tert-butyl(diphenyl)silyl]oxy}propanoyl)piperidin-4-yl]ethyl}-3H-purin-6-amine; LC-MS [M+H]+ 787.1

Provenance & Evidence