Potassium Carbonate → (2S)-1-[4-(2-{6-Amino-8-[(7-chloro-1,3-benzothiazol-2-yl)thio]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-ol

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	(1S)-2-[4-(2-{6-Amino-8-[(7-chloro-1,3-benzothiazol-2-yl)thio]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-methyl-2-oxoethyl acetate	HCID 57850093	—
Solvent	Methanol	HCID 887	—
Product	(2S)-1-[4-(2-{6-Amino-8-[(7-chloro-1,3-benzothiazol-2-yl)thio]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-ol	HCID 57850587	—

Reaction Steps

The crude product from Step 2 was suspended in methanol and K2CO3 was added and stirring continued for 2 h. The title product was isolated after preparative HPLC purification as a trifluoroacetate salt. LC-MS [M+H]+ 518.1

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07595401B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-a4500d5aa09246279f5d6199e1ff0794
Source note	uspto-grants-2009_09