Nicotinoyl chloride → HCID 10312372, compound

HRID 736683Notes

Reaction equation

FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.[CH3:22][C:23]1[CH:32]=[C:31]([CH2:33][O:34][C:35]2[CH:59]=[CH:58][C:38]([C:39]([NH:41][CH2:42][C:43]3([N:52]4[CH2:57][CH2:56][NH:55][CH2:54][CH2:53]4)[C:48](=[O:49])[NH:47][C:46](=[O:50])[NH:45][C:44]3=[O:51])=[O:40])=[CH:37][CH:36]=2)[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[N:24]=1.[C:60](Cl)(=[O:67])[C:61]1[CH:66]=[CH:65][CH:64]=[N:63][CH:62]=1>>[CH3:22][C:23]1[CH:32]=[C:31]([CH2:33][O:34][C:35]2[CH:36]=[CH:37][C:38]([C:39]([NH:41][CH2:42][C:43]3([N:52]4[CH2:53][CH2:54][N:55]([C:60]([C:61]5[CH:62]=[N:63][CH:64]=[CH:65][CH:66]=5)=[O:67])[CH2:56][CH2:57]4)[C:44](=[O:51])[NH:45][C:46](=[O:50])[NH:47][C:48]3=[O:49])=[O:40])=[CH:58][CH:59]=2)[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[N:24]=1

Participants

Reactant 2

HCID 82604Nicotinoyl chloride

HCID 86590474HCID 86590474, compound

Product 1

HCID 10312372HCID 10312372, compoundYield 85%

Procedure

Following a procedure analogous to that used in reaction (10), the material from example 8 was reacted with nicotinoyl chloride overnight to provide the title compound (13 mg, 85%). MS found: (M+H)+=622.5.

Sources & evidence

ORD record: ord-c0928224253145bdbcc0da1e285d2ab8
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07595317B2

Reaction notes

Loading…