Sodium Carbonate → 2-(4'-formylbipheny-4-yl)-1H-benzimidazole-4-carboxamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Sodium Carbonate	HCID 10340	—
Edukt	4-Formylphenylboronic Acid	HCID 591073	—
Edukt	2-(4-bromophenyl)-1H-benzimidazole-4-carboxamide	HCID 44542365	—
Katalysator	Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)	HCID 178418228	—
Lösungsmittel	1,4-Dioxane	HCID 31275	—
Produkt	2-(4'-formylbipheny-4-yl)-1H-benzimidazole-4-carboxamide	HCID 87500516	—

Reaktionsbedingungen

Temperatur	95 °C

Reaktionsschritte

A solution of EXAMPLE 3A (1.18 g, 3.8 mmol) and 4-formylphenylboronic acid (0.57 g, 3.8 mmol) in dioxane (15 mL) was treated with [1,1′-bis(diphenylphosphino)ferrocene]dichloro palladium (0.32 g, 0.4 mmol) and sodium carbonate (1.8 g, 17 mmol). The mixture was heated at 95° C. for 24 hours, then cooled and filtered. The filtrate was concentrated to provide the crude product, which was used without further purification. MS (ESI) m/e 342 (M+H)+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07595406B2
Quelldatensatz	uspto-grants-2009_09
ORD ID	ord-c3eb51b6e1c644a9a75c341c8f7ce0b4
Quellennotiz	uspto-grants-2009_09