HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 736693Erstellt: 25. Oktober 2026
Acetic Acid → 2-(5-acetylthiophen-2-yl)-1H-benzimidazole-4-carboxamide
https://huagongshe.com/reaction/736693
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Acetic Acid | HCID 176 | — |
| Edukt | 5-Acetylthiophene-2-carboxylic acid (2-amino-3-carbamoylphenyl)amide | HCID 67353795 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 2-(5-acetylthiophen-2-yl)-1H-benzimidazole-4-carboxamide | HCID 67352032 | 95,1% |
Reaktionsschritte
To a solution of EXAMPLE 6A (1.70 g) in hot N,N-dimethylformamide (60 mL) was added acetic acid (50 mL) and the solution heated at 125° C. for 3 hours. After cooling, the resulting yellow solid was collected by filtration, washed with methanol and dried to give the title compound (1.52 g, 95%). MS (APCI): 286 (M+1)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US07595406B2 |
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| Quelldatensatz | uspto-grants-2009_09 |
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| ORD ID | ord-b7c96cf3f71d4e658ec57c1905a28d2d |
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| Quellennotiz | uspto-grants-2009_09 |
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