HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cispentacin → cis-2-[({4-[(2-Methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclopentanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cispentacin | HCID 73305 | — |
| Reactant | 4-(2-Methylquinolin-4-ylmethoxy)benzenesulfonyl chloride hydrochloride | HCID 86607865 | — |
| Product | cis-2-[({4-[(2-Methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclopentanecarboxylic acid | HCID 68817794 | 84.2% |
Reaction Steps
According to the procedure of Example 10, Step 1, the reaction of 322.9 mg (2.5 mmol) of cis-2-amino-1-cyclopentane-carboxylic acid with 960.7 mg of 4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl chloride hydrochloride provided 927.7 mg of cis-2-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclopentanecarboxylic acid in 84% yield. MS: 441.1 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595327B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-7a8c8ec494e747ddae8aa5cb273f7bd6 |
| Source note | uspto-grants-2009_09 |