(1R,2S)-2-Aminocyclohexane-1-carboxylic acid → cis-2-[({4-[(2-Methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxylic acid

Participants

Reaction Steps

According to the procedure of Example 10, Step 1, the reaction of 429.6 mg (3 mmol) of cis-2-amino-1-cyclohexane-carboxylic acid with 1.15 g of 4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl chloride hydrochloride provided 387.9 mg of cis-2-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxylic acid in 28% yield. MS: 455.1 (M+H)+

Provenance & Evidence