(1S,2R)-(+)-2-Amino-1-cyclopentanecarboxylic acid hydrochloride → (1S,2R)-2-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclopentanecarboxylic acid

Participants

Reaction Steps

According to the procedure of Example 10, Step 1, the reaction of 141 mg (0.85 mmol) of (+)-(1S,2R)-2-amino-1-cyclopentane-carboxylic acid hydrochloride with 400 mg (1.04 mmol) of 4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl chloride hydrochloride provided 327.9 mg of (1S,2R)-2-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclopentanecarboxylic acid in 86% yield. MS: 441.1 (M+H)+

Provenance & Evidence