HuagongsheHuagongshe Chemistry Print Report · For research reference only
trans-2-Aminocyclohexanecarboxylic acid → trans-2-[({4-[(2-Methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | trans-2-Aminocyclohexanecarboxylic acid | HCID 2724640 | — |
| Reactant | 4-(2-Methylquinolin-4-ylmethoxy)benzenesulfonyl chloride hydrochloride | HCID 86607865 | — |
| Product | trans-2-[({4-[(2-Methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxylic acid | HCID 68819595 | 25% |
Reaction Steps
According to the procedure of Example 10, Step 1, the reaction of 486.8 mg (3.4 mmol) of trans-2-amino-1-cyclohexane-carboxylic acid with 1.31 g of 4-(2-methyl-quinolin-4-ylmethoxy)-benzenesufonyl chloride hydrochloride provided 382.7 mg of trans-2-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxylic acid in 25% yield. MS: 455.1 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595327B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-bf637295ab2043e49822a420d49572b4 |
| Source note | uspto-grants-2009_09 |