Methyl iodide → HCID 68821202, compound

HRID 736718Notes

Reaction equation

[CH3:1][C:2]1[CH:11]=[C:10]([CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([S:20]([NH:23][C@H:24]3[CH2:28][CH2:27][CH2:26][C@H:25]3[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.I[CH3:37]>>[CH3:37][N:23]([S:20]([C:17]1[CH:16]=[CH:15][C:14]([O:13][CH2:12][C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=[C:2]([CH3:1])[CH:11]=2)=[CH:19][CH:18]=1)(=[O:22])=[O:21])[C@H:24]1[CH2:28][CH2:27][CH2:26][C@H:25]1[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 68818255HCID 68818255, compound

Product 1

HCID 68821202HCID 68821202, compoundYield 93%

Procedure

According to the procedure of Example 15, Step 2, the reaction of 250.0 mg (0.5 mmol) of tert-butyl cis-2-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclopentanecarboxylate with iodomethane provided 238.0 mg of tert-butyl cis-2-[methyl({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclopentanecarboxylate in 93% yield. MS: 511.2 (M+H)+

Sources & evidence

ORD record: ord-b2a98613084a4b9fb803e3c147b00f35
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07595327B2

Reaction notes

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