Propargyl bromide → HCID 86607872, compound

Participants

Reaction Steps

According to the procedure of Example 17, Step 3, 228.2 mg of tert-butyl cis-4-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]pyrrolidine-3-carboxylate hydrochloride was reacted with 51 mg of propargyl bromide to provide 126 mg of tert-butyl cis-4-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]-1-prop-2-yn-1-ylpyrrolidine -3-carboxylate in 55% yield. MS: 536.3(M+H)+

Provenance & Evidence