Trifluoroacetic acid → cis-4-[({4-[(2-Methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]pyrrolidine-3-carboxylic acid

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Reaction Steps

To the stirred solution of 299 mg of di-tert-butyl cis-4-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]pyrrolidine-1,3-dicarboxylate (Example 17, Step 1) in 4 mL of dichloromethane was slowly added 3 mL of trifluoroacetic acid. The solution was stirred at room temperature for 3 hr. After removal of the volatile material, cis-4-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]pyrrolidine-3-carboxylic acid was obtained in quantitative yield without further purification. MS: 442.3 (M+H)+

Provenance & Evidence