HRID736735

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8022

Ethyl isocyanate

C3H5NO

结构：Cc1cc(COc2ccc(S(=O)(=O)N[C@H]3CNC[C@H]3C(=O)O)cc2)c2ccccc2n1

HCID68817812

未命名化合物

PRODUCTS

生成物

结构：CCNC(=O)N1C[C@H](NS(=O)(=O)c2ccc(OCc3cc(C)nc4ccccc34)cc2)[C@H](C(=O)O)C1

HCID68817241

未命名化合物

收率 84.7%

PROCEDURE

实验过程

According to the procedure of Example 17, Step 3, the reaction of 178 mg of cis-4-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]pyrrolidine-3-carboxylic acid (Example 21, Step 1) and 44 mg of ethyl isocyanate provided 175 mg of cis-1-[(ethylamino)carbonyl]-4-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]pyrrolidine-3-carboxylic acid in quantitative yield. MS: 513.2 (M+H)+