HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxylamine → (3S, 4R)-4-{methyl-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-amino}-tetrahydro-pyran-3-carboxylic acid hydroxyamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxylamine | HCID 787 | — |
| Reactant | HCID 68817278 | HCID 68817278 | — |
| Product | (3S, 4R)-4-{methyl-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-amino}-tetrahydro-pyran-3-carboxylic acid hydroxyamide | HCID 86607880 | 40% |
Reaction Steps
According to the procedure of Example 24, Step 3, 4-{methyl-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-amino}-tetrahydro-pyran-3-carboxylic acid (0.120 g, 0.255 mmol) and hydroxylamine provided (3S,4R)-4-{methyl-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-amino}-tetrahydro-pyran-3-carboxylic acid hydroxyamide as an amorphous white solid (0.050 g, 40%) after purification by Biotage Flash 40S chromatography, eluting with 4% methanol in ethyl acetate. MS: 486 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595327B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-69bec64aa09d487da7cda6dd31dfe01e |
| Source note | uspto-grants-2009_09 |