Lithium Hydroxide → HCID 68818793, compound

Participants

Reaction Steps

A solution of 4-{methyl-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-amino}-tetrahydro-furan-3-carboxylic acid methyl ester (0.160 g, 0.3 mmol) and lithium hydroxide (0.082 g,. 3.4 mmol) in THF:methanol:water (3: 2:2 mL) was stirred at 25° C. for 19 h. The solution was then washed with ethyl acetate (2×30 mL) and the aqueous layer was acidified with 2N HCl to pH ˜2. The aqueous layer was washed with ethyl acetate (3×40 mL). The combined organic layers were dried over MgSO4, filtered and concentrated to produce 4-{methyl-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-amino}-tetrahydro-furan-3-carboxylic acid as a crude solid (0.160 g, 100%). MS: 457 (M+H)+

Provenance & Evidence