Hydrochloric Acid → HCID 68817249, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-acetyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylamino]-piperidine-3-carboxylic acid ethyl ester (0.6 g, 1.14 mmol) in 1,4-dioxane (10 mL) was added concentrated HCl (10 mL). The reaction was heated at 60° C. for 19 h. The solvent was removed in vacuo and the residue was diluted with CH2Cl2. The organics were dried over MgSO4, filtered and concentrated. The residue was purified by reverse phase HPLC (Gilson) on a Phenomex C-18 semi-prep column eluting an acetonitrile:water gradient, to afford 1-acetyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylamino]-piperidine-3-carboxylic acid as an amorphous white solid (0.4 g, 70.1%). MS: 498 (M+H)+.

Provenance & Evidence