Hydroxylamine → HCID 11855596, compound

Participants

Reaction Steps

According to the procedure of Example 24, Step 3, 0.4 g (0.8 mmol) of 1-(2-hydroxy-ethyl)-4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylamino]-piperidine-3-carboxylic acid and hydroxylamine afforded a ˜2:1 mixture of cis- and trans-1-(2-hydroxy-ethyl)-4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylamino]-piperidine-3-carboxylic acid hydroxyamide as an amorphous white solid (0.040 g, 9.7%) after purification using reverse phase HPLC (Gilson) on a Phenomex C-18 semi-prep column eluting an acetonitrile:water gradient. MS: 515 (M+H)+.

Provenance & Evidence