Lithium Hydroxide → HCID 68817152, compound

Participants

Reaction Steps

A solution of 3-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylamino]-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (0.6 g, 1.03 mmol) and lithium hydroxide (0.148 g, 6.18 mmol) in THF:methanol:water (3:2:2 mL) was stirred at 25° C. for 19 h. The solution was then concentrated in vacuo to provide 3-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylamino]-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester as a crude solid (0.55 g, 96%). MS: 556 (M+H)+.

Provenance & Evidence