HCID 68819514, compound → 7-(1,1-Dimethylethyl) 2-methyl 3-amino-7-azabicyclo[2.2.1]heptane-2,7-dicarboxylate

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Reaction Steps

A mixture of 3-(1-phenyl-ethylamino)-7-aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester 2-methyl ester (0.28 g, 0.8 mmol) and 20% palladium hydroxide on carbon (0.2 g) in methanol (5 mL) was stirred under a hydrogen atmosphere (1 atm) for 19 h. The mixture was then filtered through a thin pad of celite and concentrated to provide 3-amino-7-aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester 2-methyl ester as a colorless oil (0.2 g, 71.4%). MS: 269 (M+H)+.

Provenance & Evidence