Lithium Hydroxide → HCID 68819139, compound

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A solution of 3-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylamino]-7-aza-bicyclo [2.2.1] heptane-2,7-dicarboxylic acid 7-tert-butyl ester 2-methyl ester (0.15 g, 2.58 mmol) and lithium hydroxide (0.062 g, 2.57 mmol) in THF:methanol:water (2.5: 1.5:1.5 mL) was stirred at 25° C. for 19 h. The solution was then concentrated in vacuo to give 3-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylamino]-7-aza-bicyclo[2.2.1] heptane-2,7-dicarboxylic acid 7-tert-butyl ester as a crude solid (0.150 g, 100%). MS: 568 (M+H)+.

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