Hydroxylamine → HCID 11855872, compound

Participants

Reaction Steps

According to the procedure of Example 24, Step 3, 0.15 g (0.26 mmol) of 3-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylamino]-7-aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester and hydroxylamine gave tert-butyl 2-[(hydroxyamino)carbonyl]-3-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]-7-azabicyclo[2.2.1]heptane-7-carboxylate as an amorphous off yellow solid (0.0162 g, 14.7%) after Biotage Flash 40S chromatography, eluting with 5% methanol in ethyl acetate. MS: 583 (M+H)+

Provenance & Evidence