Hydroxylamine → HCID 11855873, compound

Participants

Reaction Steps

According to the procedure of Example 24, Step 3, 0.05 g (0.088 mmol) of 3-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylamino]-7-aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester (Example 37, Step 5) and hydroxylamine, followed by treatment with TFA:CH2Cl2 (1:1, 0.2 mL) for 15 min, gave 3-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylamino]-7-aza-bicyclo[2.2.1]heptane-2-carboxylic acid hydroxyamide as a hygroscopic solid (0.0189 g, 37.2%). MS: 483 (M+H)+

Provenance & Evidence