Trifluoroacetic acid → HCID 86607894, compound

Participants

Reaction Steps

To a solution of tert-butyl (3R,4R)-3-[(tert-butoxyamino)carbonyl]-3-hydroxy-4-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]piperidine-1-carboxylate (740 mg, 1.15 mmol) in CH2Cl2 (10 mL) was added trifluoroacetic acid (2.5 mL). The reaction was stirred at room temperature for 1.5 h. The solvent was concentrated in vacuo and methanol was used to chase residual trifluoroacetic acid. The residue was precipitated from ether as a white solid to yield 856 mg (97%) of (3R,4R)-N-tert-butoxy-3-hydroxy-4-(4-((2-methylquinolin-4-yl) methoxy)phenylsulfonamido)piperidine-3-carboxamide as the trifluoroacetic acid salt. MS: (M+H)+=543.1.

Provenance & Evidence