Trifluoroacetic acid → HCID 86607902, compound

Participants

Reaction Conditions

Reaction Steps

To 0.092 g of (3S,4R)-N-tert-butoxy-1-formyl-3-methyl-4-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonamido)piperidine-3-carboxamide was added 3 mL of trifluoroacetic acid, and the resulting mixture was stirred at 45° C. for 8 h, and then concentrated. The residue was purified by silica chromatography (silica pre-washed with MeOH), eluting with a gradient of 5-20% MeOH/CH2Cl2 to afford (3S,4R)-1-formyl -N-hydroxy-3-methyl-4-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]piperidine-3-carboxamide (0.05 g, 60%) as a colorless solid. MS: 513.2 (M+H)+

Provenance & Evidence