Trifluoroacetic acid → HCID 57848904, compound

Participants

Reaction Conditions

Reaction Steps

To 0.11 g of (3S,4R)-N-tert-butoxy-1-(isopropylsulfonyl)-3-methyl-4-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]piperidine-3-carboxamide was added 3 mL of trifluoroacetic acid and the resulting mixture was stirred at 45° C. for 8 h. The reaction mixture was then concentrated and the residue was purified by silica chromatography (silica prewashed with MeOH) eluting with a gradient of 5-20% MeOH/CH2Cl2 to afford (3S,4R)-N-hydroxy-1-(isopropylsulfonyl)-3-methyl-4-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]piperidine-3-carboxamide (0.091 g, 83%) as a colorless solid. MS: 591.2 (M+H)+

Provenance & Evidence