Sodium Bicarbonate → HCID 86607907, compound

Participants

Reaction Steps

To a solution of methyl (1R,2R)-2-amino-1-fluorocyclopentanecarboxylate (0.47 g, 2.4 mmol, 1 eq) in CH2Cl2 (10 mL) was added 4-benzyloxy-benzenesulfonyl chloride followed by saturated sodium bicarbonate (10 mL). The reaction was stirred overnight, and then taken up in ethyl acetate. The organics were washed with brine, dried over MgSO4, filtered and concentrated. The residue was purified using silica chromatography eluting with 30% ethyl acetate/hexanes to afford methyl (1R,2R)-2-({[4-(benzyloxy)phenyl]sulfonyl}amino)-1-fluorocyclopentanecarboxylate as an off white solid (0.575 g, 60%). MS: 408.1 (M+H)+.

Provenance & Evidence